In 2004, metformin was prescribed over 40 million times. In 2020 and 2021, the annual number of prescriptions had more than doubled and exceeded more than 90 million prescriptions. Metformin is primarily used for the treatment of type 2 diabetes. This statistic shows the total annual number of metformin hydrochloride prescriptions in the U.S. from 2004 to 2022, in millions.
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ClinCalc. (August 10, 2025). Number of metformin prescriptions in the U.S. from 2004 to 2023 (in millions) [Graph]. In ÌÇÐÄÆƽâ°æ. Retrieved July 27, 2026, from /statistics/780332/metformin-hydrochloride-prescriptions-number-in-the-us/
ClinCalc. "Number of metformin prescriptions in the U.S. from 2004 to 2023 (in millions)." Chart. August 10, 2025. ÌÇÐÄÆƽâ°æ. Accessed July 27, 2026. /statistics/780332/metformin-hydrochloride-prescriptions-number-in-the-us/
ClinCalc. (2025). Number of metformin prescriptions in the U.S. from 2004 to 2023 (in millions). ÌÇÐÄÆƽâ°æ. ÌÇÐÄÆƽâ°æ Inc.. Accessed: July 27, 2026. /statistics/780332/metformin-hydrochloride-prescriptions-number-in-the-us/
ClinCalc. "Number of Metformin Prescriptions in The U.S. from 2004 to 2023 (in Millions)." ÌÇÐÄÆƽâ°æ, ÌÇÐÄÆƽâ°æ Inc., 10 Aug 2025, /statistics/780332/metformin-hydrochloride-prescriptions-number-in-the-us/
ClinCalc, Number of metformin prescriptions in the U.S. from 2004 to 2023 (in millions) ÌÇÐÄÆƽâ°æ, /statistics/780332/metformin-hydrochloride-prescriptions-number-in-the-us/ (last visited July 27, 2026)
Number of metformin prescriptions in the U.S. from 2004 to 2023 (in millions) [Graph], ClinCalc, August 10, 2025. [Online]. Available: /statistics/780332/metformin-hydrochloride-prescriptions-number-in-the-us/
