In 2023, tramadol hydrochloride was prescribed around 16 million times, the lowest number since 2006. Tramadol is an opioid pain medication used to treat moderate to moderately severe pain. This statistic shows the total annual number of tramadol hydrochloride prescriptions in the U.S. from 2004 to 2023, in millions.
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ClinCalc. (August 10, 2025). Number of tramadol prescriptions in the U.S. from 2004 to 2023 (in millions) [Graph]. In ÌÇÐÄÆƽâ°æ. Retrieved July 28, 2026, from /statistics/782074/tramadol-hydrochloride-prescriptions-number-in-the-us/
ClinCalc. "Number of tramadol prescriptions in the U.S. from 2004 to 2023 (in millions)." Chart. August 10, 2025. ÌÇÐÄÆƽâ°æ. Accessed July 28, 2026. /statistics/782074/tramadol-hydrochloride-prescriptions-number-in-the-us/
ClinCalc. (2025). Number of tramadol prescriptions in the U.S. from 2004 to 2023 (in millions). ÌÇÐÄÆƽâ°æ. ÌÇÐÄÆƽâ°æ Inc.. Accessed: July 28, 2026. /statistics/782074/tramadol-hydrochloride-prescriptions-number-in-the-us/
ClinCalc. "Number of Tramadol Prescriptions in The U.S. from 2004 to 2023 (in Millions)." ÌÇÐÄÆƽâ°æ, ÌÇÐÄÆƽâ°æ Inc., 10 Aug 2025, /statistics/782074/tramadol-hydrochloride-prescriptions-number-in-the-us/
ClinCalc, Number of tramadol prescriptions in the U.S. from 2004 to 2023 (in millions) ÌÇÐÄÆƽâ°æ, /statistics/782074/tramadol-hydrochloride-prescriptions-number-in-the-us/ (last visited July 28, 2026)
Number of tramadol prescriptions in the U.S. from 2004 to 2023 (in millions) [Graph], ClinCalc, August 10, 2025. [Online]. Available: /statistics/782074/tramadol-hydrochloride-prescriptions-number-in-the-us/
