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Keytruda, a drug from Merck & Co., was the leading drug based on revenue of about ** billion U.S. dollars in the United States in 2025. On the other hand, Stelara from Johnson & Johnson reported about **** billion dollars in revenue for the same year.

AbbVie's top products

The biopharmaceutical company responsible for the production of the drugs Skyrizi and Humira, AbbVie, generated global revenues of around ** billion U.S. dollars in 2025. Skyrizi and Humira were AbbVie’s two top products based on sales in that year, combining for around ** percent of the company’s total revenue. 

How much money is spent on medicines in the United States?

In the United States, total nominal spending on medicines exceeded *** billion U.S. dollars for the first time in 2023. Sales of branded drugs account for around ** percent of the market. Drugs can be categorized in several ways, but a common method is to group them by therapeutic area. In the United States, cancer, diabetes, and immunology are among the leading therapeutic categories based on Rx sales.