In 2025, Keytruda was the leading biotech drug worldwide and generated a total revenue of over 32 billion U.S. dollars. Dupixent ranked second with a revenue of 18 billion U.S. dollars.Â
Best-selling biotech drugs worldwide
AbbVie’s Humira is among the top-selling biotechnology drugs in the world, generating over ** billion U.S. dollars in 2023. Biotechnology has become more prevalent within the pharmaceutical industry. One of the first uses of biotechnology was for human insulin. The United States had over dedicated biotechnology companies in 2022. Among the largest biotechnology companies in the world is the Switzerland-based company Roche. The company generated ** billion U.S. dollars in biotech prescription drug revenues in 2019 and is expected to reach over ** billion U.S. dollars in 2026. One of its long-time best-selling drugs, Avastin, generated about *** billion U.S. dollars in revenue in 2023. Avastin is a drug derived from biotechnology that is used to inhibit the growth of new blood vessels to treat some types of cancer.
The United States spent about *** billion U.S. dollars on research and development in the biotechnology sector in 2021. The United States also had about ** percent of the world’s share of filed biotechnology patents in 2020; in comparison, Germany filed around * percent of global biotech patents.
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Drug Discovery & Development. (April 10, 2026). Leading selling biotech drugs worldwide in 2025 (in billion U.S. dollars) [Graph]. In ÌÇÐÄÆÆ½â°æ. Retrieved July 29, 2026, from /statistics/299138/top-selling-biotech-drugs-based-on-revenue/
Drug Discovery & Development. "Leading selling biotech drugs worldwide in 2025 (in billion U.S. dollars)." Chart. April 10, 2026. ÌÇÐÄÆÆ½â°æ. Accessed July 29, 2026. /statistics/299138/top-selling-biotech-drugs-based-on-revenue/
Drug Discovery & Development. (2026). Leading selling biotech drugs worldwide in 2025 (in billion U.S. dollars). ÌÇÐÄÆÆ½â°æ. ÌÇÐÄÆÆ½â°æ Inc.. Accessed: July 29, 2026. /statistics/299138/top-selling-biotech-drugs-based-on-revenue/
Drug Discovery & Development. "Leading Selling Biotech Drugs Worldwide in 2025 (in Billion U.S. Dollars)." ÌÇÐÄÆÆ½â°æ, ÌÇÐÄÆÆ½â°æ Inc., 10 Apr 2026, /statistics/299138/top-selling-biotech-drugs-based-on-revenue/
Drug Discovery & Development, Leading selling biotech drugs worldwide in 2025 (in billion U.S. dollars) ÌÇÐÄÆÆ½â°æ, /statistics/299138/top-selling-biotech-drugs-based-on-revenue/ (last visited July 29, 2026)
Leading selling biotech drugs worldwide in 2025 (in billion U.S. dollars) [Graph], Drug Discovery & Development, April 10, 2026. [Online]. Available: /statistics/299138/top-selling-biotech-drugs-based-on-revenue/