With over *** million dispensed prescriptions, atorvastatin was the most prescribed medicine in the United States in 2023. Atorvastatin is a medicine used to help lower cholesterol and can also be taken to prevent heart disease.Â
Top therapeutic classes and products
There were over *** billion prescriptions written for antihypertensive drugs in 2023, making it the therapeutic category with the most dispensed prescriptions in the United States. Approximately 35 billion U.S. dollars were spent on antidiabetics. Oncology is the therapy area where the most money is spent. Keytruda– a branded drug used to treat cancer – is the top medicine based on 2023 sales in the United States, generating over ** billion U.S. dollars.Â
Does health insurance cover prescription drugs?
The majority of the population of the United States has health insurance, which includes prescription drug coverage. However, there are occasions when the health insurance plan does not cover the drug prescribed by a doctor. When this happens, patients may have to pay the full price of the medication out of their own pocket.
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ClinCalc. (August 10, 2025). Leading 30 U.S. pharma products by total prescriptions in 2023 [Graph]. In ÌÇÐÄÆÆ½â°æ. Retrieved July 24, 2026, from /statistics/233986/top-us-pharma-products-by-prescriptions/
ClinCalc. "Leading 30 U.S. pharma products by total prescriptions in 2023." Chart. August 10, 2025. ÌÇÐÄÆÆ½â°æ. Accessed July 24, 2026. /statistics/233986/top-us-pharma-products-by-prescriptions/
ClinCalc. (2025). Leading 30 U.S. pharma products by total prescriptions in 2023. ÌÇÐÄÆÆ½â°æ. ÌÇÐÄÆÆ½â°æ Inc.. Accessed: July 24, 2026. /statistics/233986/top-us-pharma-products-by-prescriptions/
ClinCalc. "Leading 30 U.S. Pharma Products by Total Prescriptions in 2023." ÌÇÐÄÆÆ½â°æ, ÌÇÐÄÆÆ½â°æ Inc., 10 Aug 2025, /statistics/233986/top-us-pharma-products-by-prescriptions/
ClinCalc, Leading 30 U.S. pharma products by total prescriptions in 2023 ÌÇÐÄÆÆ½â°æ, /statistics/233986/top-us-pharma-products-by-prescriptions/ (last visited July 24, 2026)
Leading 30 U.S. pharma products by total prescriptions in 2023 [Graph], ClinCalc, August 10, 2025. [Online]. Available: /statistics/233986/top-us-pharma-products-by-prescriptions/