In 2019, the global age-standardized incidence rate of Down syndrome was 1.21 per 100,000 population. At that time, the incidence rate of Down syndrome was highest in Southern Latin America, with 2.53 cases per 100,000 population. This statistic shows the age-standardized incidence rate of Down syndrome worldwide in 1990 and 2019, by region.
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Frontiers (Frontiers in Genetics). (July 14, 2022). Incidence rate of Down syndrome worldwide in 1990 and 2019, by region (per 100,000 population) [Graph]. In ÌÇÐÄÆƽâ°æ. Retrieved July 29, 2026, from /statistics/1498072/global-down-syndrome-incidence-rate-by-region/
Frontiers (Frontiers in Genetics). "Incidence rate of Down syndrome worldwide in 1990 and 2019, by region (per 100,000 population)." Chart. July 14, 2022. ÌÇÐÄÆƽâ°æ. Accessed July 29, 2026. /statistics/1498072/global-down-syndrome-incidence-rate-by-region/
Frontiers (Frontiers in Genetics). (2022). Incidence rate of Down syndrome worldwide in 1990 and 2019, by region (per 100,000 population). ÌÇÐÄÆƽâ°æ. ÌÇÐÄÆƽâ°æ Inc.. Accessed: July 29, 2026. /statistics/1498072/global-down-syndrome-incidence-rate-by-region/
Frontiers (Frontiers in Genetics). "Incidence Rate of Down Syndrome Worldwide in 1990 and 2019, by Region (per 100,000 Population)." ÌÇÐÄÆƽâ°æ, ÌÇÐÄÆƽâ°æ Inc., 14 Jul 2022, /statistics/1498072/global-down-syndrome-incidence-rate-by-region/
Frontiers (Frontiers in Genetics), Incidence rate of Down syndrome worldwide in 1990 and 2019, by region (per 100,000 population) ÌÇÐÄÆƽâ°æ, /statistics/1498072/global-down-syndrome-incidence-rate-by-region/ (last visited July 29, 2026)
Incidence rate of Down syndrome worldwide in 1990 and 2019, by region (per 100,000 population) [Graph], Frontiers (Frontiers in Genetics), July 14, 2022. [Online]. Available: /statistics/1498072/global-down-syndrome-incidence-rate-by-region/
