
Matej Mikulic
Research expert covering health, pharma & medtech

Detailed statistics
Pharmaceuticals: cost of drug development in the U.S. since 1975

Detailed statistics
Total global pharmaceutical R&D spending 2016-2030

Detailed statistics
Number of drugs in the R&D pipeline worldwide 2001-2026

Total global pharmaceutical R&D spending 2016-2030
Total global spending on pharmaceutical research and development from 2016 to 2030 (in billion U.S. dollars)

Industry sectors - expenditure on research and development 2024
Percentage of spending on research and development of total revenue in 2024, by industrial sector

Major pharmaceutical R&D projects 2026, by net present value
Leading pharmaceutical R&D projects based on net present value (NPV) as of May 2026 (in billion U.S. dollars)

Research and development expenditure: U.S. pharmaceutical industry 1995-2024
Research and development expenditure of total U.S. pharmaceutical industry from 1995 to 2024 (in billion U.S. dollars)

Research and development in European pharmaceutical industry by country 2024
Pharmaceutical research and development spending in selected European countries in 2024 (in million euros)

Clinical trials market size worldwide 2024-2033
Global market size forecast for clinical trials from 2024 to 2033 (in billion U.S. dollars)

Total clinical research funding by National Institutes for Health 2013-2024
Total clinical research funding by the National Institutes for Health (NIH) from FY 2013 to FY 2024 (in million U.S. dollars)

Leading 50 global pharmaceutical and biotech companies 2024, by R&D intensity
Leading 50 pharmaceutical and biotechnology companies worldwide in 2024, by R&D intensity

Major pharmaceutical companies in R&D spending growth in 2024
Leading 50 pharmaceutical and biotechnology companies worldwide in 2024, by R&D spending growth

Leading global contract research organizations 2025, based on revenue
Leading global contract research organizations (CROs) 2025, based on revenue (in million U.S. dollars)

Increase in clinical trials' complexity 2001-2015
Increase in clinical trials' complexity between 2001-2005 and 2011-2015

Clinical trial success rates by therapeutic area 2020
Clinical trial success rates by therapeutic area as of 2020

Number of registered clinical studies by location worldwide 2026
Number of registered clinical studies worldwide by location as of January 2026

Percent of registered clinical studies worldwide by location 2026
Percentage of registered clinical studies worldwide by location as of January 2026

Total number of registered clinical studies worldwide 2000-2025
Total number of registered clinical studies worldwide from 2000 to 2025

Share of global clinical trials as of March 2025, by intervention type
Share of clinical trials worldwide as of March 2025, by type of intervention/treatment

Share of global clinical trials by primary purpose 2025
Share of clinical trials worldwide as of March 2025, by primary purpose

Pharmaceuticals: cost of drug development in the U.S. since 1975
Cost of developing a drug in the U.S. from the 1970s until today (in million U.S. dollars)

Per day clinical trial mean direct cost by phase
Clinical trial per day mean direct cost in the U.S. in 2023, by phase (in U.S. dollars)

Total CRO market size worldwide 2015-2024
Total contract research organization (CRO) market worldwide from 2015 to 2024 (in million U.S. dollars)

Global pharma CRO market size 2015-2024, by pre-clinical, clinical and discovery
Global pharmaceutical CRO market size from 2015 to 2024, by pre-clinical, clinical and discovery (in billion U.S. dollars)

Share of clinical trials started worldwide 2013-2023, by region
Geographical distribution of clinical trials started worldwide from 2013 to 2023, by region

Share of commercial clinical trial starts worldwide 2013-2023, by region
Share of commercial clinical trial starts worldwide from 2013 to 2023, by region

Number of commercial clinical trial starts in top countries 2023 vs 2018
Number of commercial clinical trial starts in top countries in 2023 vs. 2018

Number of clinical trials APAC 1999-2025, by country
Number of clinical trials conducted in the Asia-Pacific region between 1999 and 2025, by country

Clinical studies in Latin America 2025, by country
Number of registered clinical studies in Latin America as of June 2025, by country

Pharmaceutical industry - number of new substances 1998-2025
Number of new chemical or biological entities developed between 1998 and 2025, by region of origin

Number of novel drugs approved annually by CDER 2008-2025
Total number of novel drugs approved by CDER from 2008 to 2025

Key measurements of U.S. CDER drug approvals in 2025
Percentage of drugs approved by the U.S. Center for Drug Evaluation and Research (CDER) in 2025 that met select key measurements

Major pharma and biotech drug launches in 2026, by revenue estimates for 2032
Major pharma and biotech drug launches in 2026, by revenue estimates for 2032 (in billion U.S. dollars)

Number of unsuccessful Alzheimer’s drugs in development in the U.S. 1998-2017
Number of unsuccessful Alzheimer’s drugs in development in the U.S. from 1998 to 2017

Leading AI in clinical trials companies by funding worldwide 2023
Select leading AI in clinical trials companies by funding as of 2023 (in million U.S. dollars)

AI-based clinical trials solutions market worldwide 2030 forecast
Global market for AI-based solutions in clinical trials in 2021 and a forecast for 2030 (in billion U.S. dollars)

Number of clinical trials globally that have included mentions of AI 2014-2024
Clinical trials that have mentioned artificial intelligence (AI) worldwide from 2014 to 2024

Number of clinical trials that have included mentions of AI 2014-2024, by country
Clinical trials that have mentioned artificial intelligence (AI) worldwide from 2021 to 2024, by select geographic areas

Global AI-enabled drug discovery and clinical trials market by region 2030
Forecasted AI-enabled drug discovery and clinical trials market share worldwide by region in 2030
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