EFPIA stands for the European Federation of Pharmaceutical Industries and Associations.
This statistic was assembled from several editions of this report.
* First period for which a separated value for China was provided.
Citation formats
Pharmaceutical industry - number of new substances 1998-2025
Between 2021 and 2025, American companies introduced a total of *** new chemical or biological substances. Within the same period, Europe and Japan produced **Ìý²¹²Ô»å ** new entities, respectively.Â
Total R&D spending
In 2026, the global pharmaceutical industry spent an estimated *** billion U.S. dollars on research and development. Global pharmaceutical R&D expenditures have been increasing with (almost) each consecutive year since 2012 and are expected to keep growing: worldwide R&D spending is projected to reach over *** billion U.S. dollars by 2030.Â
Patent expiration
Once the patent protection date of a branded drug expires, other pharmaceutical companies can take this opportunity to make cheaper versions of the original (a.k.a. generics). In 2025, about ** billion U.S. dollars’ worth of prescription drug revenues were estimated to be at risk due to patent expiration worldwide.
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EFPIA. (June 24, 2026). Number of new chemical or biological entities developed between 1998 and 2025, by region of origin [Graph]. In ÌÇÐÄÆƽâ°æ. Retrieved July 28, 2026, from /statistics/275262/pharmaceutical-industry-new-entities-by-region/
EFPIA. "Number of new chemical or biological entities developed between 1998 and 2025, by region of origin." Chart. June 24, 2026. ÌÇÐÄÆƽâ°æ. Accessed July 28, 2026. /statistics/275262/pharmaceutical-industry-new-entities-by-region/
EFPIA. (2026). Number of new chemical or biological entities developed between 1998 and 2025, by region of origin. ÌÇÐÄÆƽâ°æ. ÌÇÐÄÆƽâ°æ Inc.. Accessed: July 28, 2026. /statistics/275262/pharmaceutical-industry-new-entities-by-region/
EFPIA. "Number of New Chemical or Biological Entities Developed between 1998 and 2025, by Region of Origin." ÌÇÐÄÆƽâ°æ, ÌÇÐÄÆƽâ°æ Inc., 24 Jun 2026, /statistics/275262/pharmaceutical-industry-new-entities-by-region/
EFPIA, Number of new chemical or biological entities developed between 1998 and 2025, by region of origin ÌÇÐÄÆƽâ°æ, /statistics/275262/pharmaceutical-industry-new-entities-by-region/ (last visited July 28, 2026)
Number of new chemical or biological entities developed between 1998 and 2025, by region of origin [Graph], EFPIA, June 24, 2026. [Online]. Available: /statistics/275262/pharmaceutical-industry-new-entities-by-region/
