
Conor Stewart
Research expert covering health & pharmaceuticals in the UK & Europe
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In 2024, around 47.7 thousand people in the United States died from a drug overdose that involved fentanyl. Although this was a signifiacnt drop from the preceding year, it was still the fifith-highest number of fentanyl overdose deaths ever recorded in the United States. Fentanyl overdoses are now the driving force behind the opioid epidemic, accounting for the majority of overdose deaths in the United States.
Fentanyl is an extremely potent synthetic opioid similar to morphine, but more powerful. It is a prescription drug but is also manufactured illegally and is sometimes mixed with other illicit drugs such as heroin and cocaine, often without the user’s knowledge. The potency of fentanyl makes it very addictive and puts users at a high risk for overdose. Illegally manufactured fentanyl has become more prevalent in the United States in recent years, leading to a huge increase in drug overdose deaths. In 2023, the rate of drug overdose death involving fentanyl was 22.2 per 100,000 population, compared to a rate of just one per 100,000 population in the year 2013.
As of 2023, the rate of drug overdose deaths involving fentanyl in the United States is over two times higher among men than women. Rates of overdose death involving fentanyl were low for both men and women until around the year 2014 when they began to quickly increase, especially for men. In 2022, there were around 19,420 drug overdose deaths among women that involved fentanyl compared to 53,356 such deaths among men. At that time, the rate of fentanyl overdose deaths was highest among non-Hispanic American Indian or Alaska Natives and lowest among non-Hispanic Asians. However, from the years 2014 to 2018, non-Hispanic whites had the highest fentanyl overdose death rates.
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U.S. overview
Heroin
Prescription opioids
Overview of deaths from opioids
Fentanyl
Nonfatal drug overdose
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1 All prices do not include sales tax. The account requires an annual contract and will renew after one year to the regular list price.