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In 2020, the southern region of the U.S. had the highest number of drug overdose deaths involving illegally manufactured fentanyl and analogs, with 8,816 male and 3,488 female deaths. Males suffered more overdose drug deaths than females in all U.S. regions in that year. This statistic shows the number of drug overdose deaths that involved illicitly manufactured fentanyls in the U.S. in 2020, by region and gender.