Key insights
- Year that smallpox was eradicated
- 1980

Detailed statistics
Number of smallpox cases worldwide 1920-1980
- Diseases prevented by DTP1
- Diphtheria, tetanus, and pertussis

Detailed statistics
Number of vaccine-preventable disease cases worldwide 1980-2024, by disease
- Global DTP1 vaccination coverage
- 89%

Detailed statistics
Vaccination coverage Americas vs globally 2022, by vaccine type
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Current statistics on this topic
Recommended statistics
Overview
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- Number of vaccine-preventable disease cases worldwide 1980-2024, by disease
- Global vaccination coverage in 2022, by vaccine type
- Vaccination coverage Americas vs globally 2022, by vaccine type
- Vaccination coverage among U.S. adolescents as of 2024, by age
- Cases of vaccine-preventable diseases in the U.S. from 1980 to 2022, by disease
- Cases of infectious diseases before and after the use of vaccines U.S. 2022
- Major causes of death in the U.S. for 1900 and 2024
Overview
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Number of vaccine-preventable disease cases worldwide 1980-2024, by disease

Number of vaccine-preventable disease cases worldwide 1980-2024, by disease
Reported cases of vaccine-preventable diseases worldwide from 1980 to 2024, by disease
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Global vaccination coverage in 2022, by vaccine type

Global vaccination coverage in 2022, by vaccine type
Routine vaccination coverage globally as of 2022, by vaccine type*
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Vaccination coverage Americas vs globally 2022, by vaccine type

Vaccination coverage Americas vs globally 2022, by vaccine type
Routine vaccination coverage in the Americas compared to worldwide as of 2022, by vaccine type*
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Vaccination coverage among U.S. adolescents as of 2024, by age

Vaccination coverage among U.S. adolescents as of 2024, by age
Percentage of adolescents in the U.S. who had received select vaccinations as of 2024, by age
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Cases of vaccine-preventable diseases in the U.S. from 1980 to 2022, by disease

Cases of vaccine-preventable diseases in the U.S. from 1980 to 2022, by disease
Reported cases of select vaccine-preventable diseases in the U.S. from 1980 to 2022, by disease
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Cases of infectious diseases before and after the use of vaccines U.S. 2022

Cases of infectious diseases before and after the use of vaccines U.S. 2022
Annual number of cases of select infectious diseases in the U.S. before and after the development and use of vaccinations as of 2022
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Major causes of death in the U.S. for 1900 and 2024

Major causes of death in the U.S. for 1900 and 2024
Leading causes of death in the U.S. in 1900 and 2024 (per 100,000 population)
Global disease incidence
11
- Incidence of tuberculosis worldwide by region 2024
- Positive influenza cases per week worldwide in 2021, by type
- Number of measles cases worldwide from 1980 to 2024, by region
- Number of mumps cases worldwide from 1999 to 2024, by region
- Number of rubella cases worldwide from 1999 to 2023, by region
- Number of cases of diphtheria worldwide from 1980 to 2024, by region
- Number of tetanus cases worldwide from 1980 to 2024, by region
- Number of pertussis (whooping cough) cases worldwide from 1980 to 2024, by region
- Number of polio cases worldwide from 1980 to 2024, by region
- Number of smallpox cases worldwide 1920-1980
- Number of countries where smallpox was eradicated in nature 1872-1977
Global disease incidence
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Incidence of tuberculosis worldwide by region 2024

Incidence of tuberculosis worldwide by region 2024
Incidence of tuberculosis worldwide in 2024, by region (per 100,000 population)
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Positive influenza cases per week worldwide in 2021, by type

Positive influenza cases per week worldwide in 2021, by type
Reported cases of influenza per week in 2021 worldwide, by type
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Number of measles cases worldwide from 1980 to 2024, by region

Number of measles cases worldwide from 1980 to 2024, by region
Reported cases of measles worldwide from 1980 to 2024, by region
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Number of mumps cases worldwide from 1999 to 2024, by region

Number of mumps cases worldwide from 1999 to 2024, by region
Confirmed cases of mumps worldwide from 1999 to 2024, by region
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Number of rubella cases worldwide from 1999 to 2023, by region

Number of rubella cases worldwide from 1999 to 2023, by region
Reported cases of rubella worldwide from 1999 to 2023, by region
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Number of cases of diphtheria worldwide from 1980 to 2024, by region

Number of cases of diphtheria worldwide from 1980 to 2024, by region
Confirmed cases of diphtheria worldwide from 1980 to 2024, by region
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Number of tetanus cases worldwide from 1980 to 2024, by region

Number of tetanus cases worldwide from 1980 to 2024, by region
Reported cases of tetanus worldwide from 1980 to 2024, by region
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Number of pertussis (whooping cough) cases worldwide from 1980 to 2024, by region

Number of pertussis (whooping cough) cases worldwide from 1980 to 2024, by region
Reported cases of pertussis (whooping cough) worldwide from 1980 to 2024, by region
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Number of polio cases worldwide from 1980 to 2024, by region

Number of polio cases worldwide from 1980 to 2024, by region
Reported cases of polio worldwide from 1980 to 2024, by region
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Number of smallpox cases worldwide 1920-1980

Number of smallpox cases worldwide 1920-1980
Reported number of smallpox cases globally between 1920 and 1980
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Number of countries where smallpox was eradicated in nature 1872-1977

Number of countries where smallpox was eradicated in nature 1872-1977
Number of countries in which naturally occurring cases of smallpox were eradicated between 1872 and 1977
Tuberculosis (BCG Immunization)
5
Tuberculosis (BCG Immunization)
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Number of new cases of tuberculosis in the U.S. 1953-2023

Number of new cases of tuberculosis in the U.S. 1953-2023
Number of new cases of tuberculosis in the U.S. from 1953 to 2023
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Rate of new cases of tuberculosis in the U.S. 1953-2024

Rate of new cases of tuberculosis in the U.S. 1953-2024
New cases of tuberculosis per 100,000 population in the U.S. from 1953 to 2024
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New cases of tuberculosis in the U.S. 2023, by state

New cases of tuberculosis in the U.S. 2023, by state
New cases of tuberculosis per 100,000 population in the U.S. in 2023, by state
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New cases of tuberculosis in the U.S. from 2016 to 2023, by national origin

New cases of tuberculosis in the U.S. from 2016 to 2023, by national origin
Tuberculosis case count in the U.S. from 2016 to 2023, by national origin*
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Death rate for tuberculosis in the U.S. 1960-2022

Death rate for tuberculosis in the U.S. 1960-2022
Tuberculosis death rate in the United States from 1960 to 2022 (per 100,000 population)
Influenza (HiB Immunization)
8
- Flu vaccine coverage in the U.S. 2014-2025, by age
- Percentage of U.S. older people who received influenza vaccination 2010-2025
- Number of influenza cases in the United States from 2011-2025
- Number of influenza hospitalizations in the United States from 2011-2024
- Number of influenza deaths in the United States from 2010-2025
- Deaths by influenza and pneumonia in the U.S. 1950-2023
- Number of influenza vaccinations needed to prevent one hospitalization U.S. 2018-2019
- Number of deaths prevented by influenza vaccinations U.S. 2023-2024, by age
Influenza (HiB Immunization)
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Flu vaccine coverage in the U.S. 2014-2025, by age

Flu vaccine coverage in the U.S. 2014-2025, by age
Percentage of individuals with a flu vaccine in the U.S. from 2014 to 2025, by age
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Percentage of U.S. older people who received influenza vaccination 2010-2025

Percentage of U.S. older people who received influenza vaccination 2010-2025
Percentage of older people who received an influenza vaccination during the flu season in the U.S. from 2010/11 to 2024/25
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Number of influenza cases in the United States from 2011-2025

Number of influenza cases in the United States from 2011-2025
Estimated number of influenza cases in the United States from 2011 to 2025 (in millions)
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Number of influenza hospitalizations in the United States from 2011-2024

Number of influenza hospitalizations in the United States from 2011-2024
Number of influenza hospitalizations in the United States from 2011 to 2024
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Number of influenza deaths in the United States from 2010-2025

Number of influenza deaths in the United States from 2010-2025
Number of influenza deaths in the United States from 2010 to 2025
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Deaths by influenza and pneumonia in the U.S. 1950-2023

Deaths by influenza and pneumonia in the U.S. 1950-2023
Deaths by influenza and pneumonia in the U.S. from 1950 to 2023 (per 100,000 population)
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Number of influenza vaccinations needed to prevent one hospitalization U.S. 2018-2019

Number of influenza vaccinations needed to prevent one hospitalization U.S. 2018-2019
Number of influenza vaccinations needed to prevent one influenza A (H1N1)-associated hospitalization in the U.S. from 2018 to 2019, by age group
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Number of deaths prevented by influenza vaccinations U.S. 2023-2024, by age

Number of deaths prevented by influenza vaccinations U.S. 2023-2024, by age
Number of influenza A- and B-associated deaths prevented by influenza vaccination in the U.S. from 2023 to 2024, by age group
Measles Mumps and Rubella (MMR Immunization)
7
- MMR vaccination rate among U.S. children aged 19-35 months 1995-2017
- New cases of measles in the U.S. 1985-2026
- Rate of new cases of measles in the U.S. 1919-2026
- Number of measles cases in the U.S. in 2021, by region
- New cases of mumps in the U.S. 1970-2019
- Number of mumps cases in the U.S. in 2021, by region
- Number of rubella cases in the U.S. from 1998 to 2023
Measles Mumps and Rubella (MMR Immunization)
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MMR vaccination rate among U.S. children aged 19-35 months 1995-2017

MMR vaccination rate among U.S. children aged 19-35 months 1995-2017
Percentage of children aged 19-35 months who are vaccinated against measles, mumps and rubella (MMR) in the U.S. from 1995 to 2017
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New cases of measles in the U.S. 1985-2026

New cases of measles in the U.S. 1985-2026
Number of new cases of measles (rubeola) in the U.S. from 1985 to February 2026
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Rate of new cases of measles in the U.S. 1919-2026

Rate of new cases of measles in the U.S. 1919-2026
Rate of new measles cases in the U.S. from 1919 to 2026 (per 100,000 population)
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Number of measles cases in the U.S. in 2021, by region

Number of measles cases in the U.S. in 2021, by region
Number of cases of measles reported in the United States in 2021, by region*
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New cases of mumps in the U.S. 1970-2019

New cases of mumps in the U.S. 1970-2019
New cases of mumps per 100,000 population in the U.S. from 1970 to 2019
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Number of mumps cases in the U.S. in 2021, by region

Number of mumps cases in the U.S. in 2021, by region
Number of cases of mumps reported in the United States in 2021, by region
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Number of rubella cases in the U.S. from 1998 to 2023

Number of rubella cases in the U.S. from 1998 to 2023
Reported cases of rubella in the U.S. from 1998 to 2023
Diphtheria Tetanus and Pertussis (DTP3 Immunization)
8
- DTP3 immunization coverage in the U.S. from 2000 to 2023
- New cases of diphtheria in the U.S. 1950-2019
- Number of diphtheria deaths in the U.S. from 1990 to 2019
- Number of U.S. tetanus cases from 1980 to 2023
- Number of tetanus deaths in the U.S. from 1990 to 2019
- Cases of pertussis in the U.S. 1950-2019
- Rate of pertussis among U.S. population by state 2018
- Number of whooping cough deaths in the U.S. from 1990 to 2019
Diphtheria Tetanus and Pertussis (DTP3 Immunization)
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DTP3 immunization coverage in the U.S. from 2000 to 2023

DTP3 immunization coverage in the U.S. from 2000 to 2023
Diphtheria tetanus toxoid and pertussis (DTP3) immunization coverage among one-year-olds in the U.S. 2000-2023*
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New cases of diphtheria in the U.S. 1950-2019

New cases of diphtheria in the U.S. 1950-2019
New cases of diphtheria per 100,000 population in the U.S. from 1950 to 2019
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Number of diphtheria deaths in the U.S. from 1990 to 2019

Number of diphtheria deaths in the U.S. from 1990 to 2019
Estimated number of deaths caused by diphtheria in the United States from 1990 to 2019, by year
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Number of U.S. tetanus cases from 1980 to 2023

Number of U.S. tetanus cases from 1980 to 2023
Reported cases of tetanus in the United States from 1980 to 2023
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Number of tetanus deaths in the U.S. from 1990 to 2019

Number of tetanus deaths in the U.S. from 1990 to 2019
Estimated number of deaths caused by tetanus in the United States from 1990 to 2019, by year
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Cases of pertussis in the U.S. 1950-2019

Cases of pertussis in the U.S. 1950-2019
New cases of pertussis (whooping cough) per 100,000 population in the U.S. from 1950 to 2019
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Rate of pertussis among U.S. population by state 2018

Rate of pertussis among U.S. population by state 2018
Pertussis rate in the United States as of 2018, by state (new cases per 100,000 population)
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Number of whooping cough deaths in the U.S. from 1990 to 2019

Number of whooping cough deaths in the U.S. from 1990 to 2019
Estimated number of deaths caused by whooping cough (pertussis) in the United States from 1990 to 2019, by year
Hepatitis A and B
7
- Hepatitis B immunization coverage in the U.S. among one-year-olds, 2000-2023
- Rate of hepatitis B infections in the U.S. in 2023, by state
- Rate of hepatitis B-related deaths in the U.S. in 2023, by age
- Hepatitis A infection rate in the U.S. in 2023, by state
- Rate of hepatitis A-related deaths in the U.S. in 2023, by age
- New cases of hepatitis A and B 1970-2023
- Rate of viral hepatitis-related deaths in the U.S. from 2019-2023, by type
Hepatitis A and B
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Hepatitis B immunization coverage in the U.S. among one-year-olds, 2000-2023

Hepatitis B immunization coverage in the U.S. among one-year-olds, 2000-2023
Hepatitis B (HepB3) immunization coverage among one-year-olds in the United States from 2000 to 2023, by year
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Rate of hepatitis B infections in the U.S. in 2023, by state

Rate of hepatitis B infections in the U.S. in 2023, by state
Rate of viral hepatitis B infections in the U.S. in 2023, by state (per 100,000 population)
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Rate of hepatitis B-related deaths in the U.S. in 2023, by age

Rate of hepatitis B-related deaths in the U.S. in 2023, by age
Rate of viral hepatitis B-related deaths in the U.S. in 2023, by age (per 100,000 population)
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Hepatitis A infection rate in the U.S. in 2023, by state

Hepatitis A infection rate in the U.S. in 2023, by state
Rate of viral hepatitis A infection in the U.S. in 2023, by state (per 100,000 population)
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Rate of hepatitis A-related deaths in the U.S. in 2023, by age

Rate of hepatitis A-related deaths in the U.S. in 2023, by age
Rate of viral hepatitis A-related deaths in the U.S. in 2023, by age (per 100,000 population)
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New cases of hepatitis A and B 1970-2023

New cases of hepatitis A and B 1970-2023
New cases of hepatitis A and B per 100,000 population in the U.S. from 1970 to 2023
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Rate of viral hepatitis-related deaths in the U.S. from 2019-2023, by type

Rate of viral hepatitis-related deaths in the U.S. from 2019-2023, by type
Rate of viral hepatitis-related deaths in the U.S. from 2019 to 2023, by type (per 100,000 population)
Human Papilloma Virus (HPV Immunization)
7
- HPV vaccine coverage among U.S. adolescents as of 2024, by age
- Share of U.S. college students vaccinated against HPV as of fall 2025, by gender
- U.S. adults who received the recommended doses of the HPV vaccine 2013-2018 by gender
- Number of cancer cases that were caused by HPV in the U.S. 2017-2021, by site
- Percentage of select cancers that were caused by HPV in the U.S. 2017-2021, by gender
- Percentage of select cancers that were caused by HPV in the U.S. 2017-2021, by site
- U.S. rate of new alcohol-associated cancers in 2022, by state
Human Papilloma Virus (HPV Immunization)
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HPV vaccine coverage among U.S. adolescents as of 2024, by age

HPV vaccine coverage among U.S. adolescents as of 2024, by age
Percentage of adolescents in the U.S. who had received an HPV vaccine as of 2024, by age*
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Share of U.S. college students vaccinated against HPV as of fall 2025, by gender

Share of U.S. college students vaccinated against HPV as of fall 2025, by gender
Percentage of college students in the U.S. who had been vaccinated against Human Papillomavirus (HPV), as of fall 2025, by gender
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U.S. adults who received the recommended doses of the HPV vaccine 2013-2018 by gender

U.S. adults who received the recommended doses of the HPV vaccine 2013-2018 by gender
Share of adults aged 18-26 in the U.S. who received the recommended number of doses of human papillomavirus vaccine between 2013 and 2018, by gender
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Number of cancer cases that were caused by HPV in the U.S. 2017-2021, by site

Number of cancer cases that were caused by HPV in the U.S. 2017-2021, by site
Number of select cancer cases that were probably caused by HPV in the U.S. per year from 2017 to 2021, by site
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Percentage of select cancers that were caused by HPV in the U.S. 2017-2021, by gender

Percentage of select cancers that were caused by HPV in the U.S. 2017-2021, by gender
Percentage of HPV-related cancers that were probably caused by HPV in the U.S. per year from 2017 to 2021, by gender*
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Percentage of select cancers that were caused by HPV in the U.S. 2017-2021, by site

Percentage of select cancers that were caused by HPV in the U.S. 2017-2021, by site
Percentage of select cancers that were probably caused by HPV in the U.S. per year from 2017 to 2021, by site
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U.S. rate of new alcohol-associated cancers in 2022, by state

U.S. rate of new alcohol-associated cancers in 2022, by state
Rate of new alcohol-associated cancers in the United States in 2022, by state (per 100,000 people)
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