Pre-vaccine era estimates range from the years 1900 to 1969. Recent estimates were taken from the CDC's National Notifiable Diseases Surveillance System (NNDSS) annual summary data and can be
Release date represents the date figures were compiled.
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Cases of infectious diseases before and after the use of vaccines U.S. 2022
This statistic shows the annual number of cases of select infectious diseases in the U.S. before and after the development and use of vaccinations as of 2022. Before the use of vaccinations there were an estimated 530,217 new cases of measles per year in the United States. This number dropped to 121 new cases in 2022 due to the development and use of vaccinations.
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Pfizer, & CDC (National Notifiable Diseases Surveillance System (NNDSS)). (March 6, 2025). Annual number of cases of select infectious diseases in the U.S. before and after the development and use of vaccinations as of 2022 [Graph]. In ÌÇÐÄÆƽâ°æ. Retrieved July 26, 2026, from /statistics/663873/infectious-disease-cases-before-and-after-use-of-vaccination-us/
Pfizer, und CDC (National Notifiable Diseases Surveillance System (NNDSS)). "Annual number of cases of select infectious diseases in the U.S. before and after the development and use of vaccinations as of 2022." Chart. March 6, 2025. ÌÇÐÄÆƽâ°æ. Accessed July 26, 2026. /statistics/663873/infectious-disease-cases-before-and-after-use-of-vaccination-us/
Pfizer, CDC (National Notifiable Diseases Surveillance System (NNDSS)). (2025). Annual number of cases of select infectious diseases in the U.S. before and after the development and use of vaccinations as of 2022. ÌÇÐÄÆƽâ°æ. ÌÇÐÄÆƽâ°æ Inc.. Accessed: July 26, 2026. /statistics/663873/infectious-disease-cases-before-and-after-use-of-vaccination-us/
Pfizer, and CDC (National Notifiable Diseases Surveillance System (NNDSS)). "Annual Number of Cases of Select Infectious Diseases in The U.S. before and after The Development and Use of Vaccinations as of 2022." ÌÇÐÄÆƽâ°æ, ÌÇÐÄÆƽâ°æ Inc., 6 Mar 2025, /statistics/663873/infectious-disease-cases-before-and-after-use-of-vaccination-us/
Pfizer & CDC (National Notifiable Diseases Surveillance System (NNDSS)), Annual number of cases of select infectious diseases in the U.S. before and after the development and use of vaccinations as of 2022 ÌÇÐÄÆƽâ°æ, /statistics/663873/infectious-disease-cases-before-and-after-use-of-vaccination-us/ (last visited July 26, 2026)
Annual number of cases of select infectious diseases in the U.S. before and after the development and use of vaccinations as of 2022 [Graph], Pfizer, & CDC (National Notifiable Diseases Surveillance System (NNDSS)), March 6, 2025. [Online]. Available: /statistics/663873/infectious-disease-cases-before-and-after-use-of-vaccination-us/
