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This report presents key facts and figures about vaccine hesitancy in the United States. Vaccine hesitancy refers to vaccine reluctance or refusal, usually due to misconceptions about the safety or effectiveness of vaccines. The anti-vaccination movement has grown in recent years in places such as the United States and Europe, despite overwhelming evidence of the effectiveness of vaccinations. The COVID-19 pandemic proved just how prevalent vaccine hesitancy is, as large shares of people around the world expressed hesitancy at recieving a vaccination against the virus. This report contains a brief overview of vaccine hesitancy worldwide before focusing specifically on the United States, providing information on reasons for vaccine hesitancy, refusals and exemptions, petitions filed for injuries and deaths caused by vaccines, and public opinion, and a special focus on vaccine hesitancy during the COVID-19 pandemic.