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The largest outbreak of Ebola virus since 1976 was the West African Epidemic, which occurred in Guinea, Liberia, and Sierra Leone between 2014 and 2016. The outbreak resulted in * cases and **deaths. The outbreak started in Guinea and spread rapidly to surrounding countries.

A current outbreak in DR Congo and Uganda has been listed as a 'public health emergency of international concern' by the WHO, with over confirmed cases reported as of July 16, 2026.

Ebola Virus Disease

Ebola Virus Disease (EVD) is a viral pathogen that causes fever, headaches, severe abdominal pain, and, in some cases, hemorrhaging. It is transmitted from human to human through contact with infected body fluids, infected objects, or semen from a recovered EVD patient. Ebola infection has several stages, including incubation, illness, and infectiousness. It is estimated that the mean time from Ebola exposure to the onset of symptoms is approximately seven days. Of the five types of Ebola, the Zaire ebolavirus has been shown to be the deadliest.

2014-2016 Ebola Outbreak

The West African Ebola outbreak of 2014–2016 was the largest outbreak in history. As of 2016, it was estimated that Sierra Leone had the most Ebola-associated deaths, followed by Guinea. The outbreak began in Guinea in January 2014. However, it progressed rapidly, and by March 30, 2016, Liberia had experienced over ** thousand cases. Throughout the 2014-2016 epidemic, healthcare workers were disproportionately affected by the disease. By November 4, 2015, there were almost *** cases of Ebola virus disease among healthcare workers.