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Ranking of rare diseases with the highest number of affected individuals in Spain in 2025

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Release date

2025

Region

Spain

Survey time period

2025

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Number of people affected by rare diseases in Spain in 2025

Published by
Conor Stewart,
Jan 23, 2026

The most common rare disease in Spain is toxic oil syndrome, although it is not considered as such by some organizations.
This disease currently affects nearly * people and originated in the early eighties, when a mass poisoning occurred due to the ingestion of denatured rapeseed oil fraudulently marketed for human consumption in Spain. It caused the death of approximately people.

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