Products that have orphan and non-orphan drug
designations and are expected to generate less than 50% of their sales in 2024 from
their orphan-designated indication/s, are excluded from this statistic. This has led to the exclusion of therapies such as Avastin, Opdivo, Enbrel, Herceptin, Humira and Remicade.
Citation formats
Top 10 companies by global revenue from orphan drugs 2030
This statistic shows a projection of the top 10 global pharmaceutical companies based on revenue generated by orphan drugs in 2030. For that year, it is projected that Roche's orphan drugs revenue will total **** billion U.S. dollars. Orphan drugs are used to target rare diseases or disorders, which in the United States is defined as less than ** patients. The development of orphan drugs is currently incentivized in the United States through the Orphan Drug Act of 1983.
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Evaluate. (March 14, 2025). Forecast of leading 10 pharmaceutical companies by global orphan drug revenue in 2030 (in billion U.S. dollars) [Graph]. In ÌÇÐÄÆƽâ°æ. Retrieved July 30, 2026, from /statistics/373366/projected-top-10-companies-based-on-global-orphan-drug-revenue/
Evaluate. "Forecast of leading 10 pharmaceutical companies by global orphan drug revenue in 2030 (in billion U.S. dollars)." Chart. March 14, 2025. ÌÇÐÄÆƽâ°æ. Accessed July 30, 2026. /statistics/373366/projected-top-10-companies-based-on-global-orphan-drug-revenue/
Evaluate. (2025). Forecast of leading 10 pharmaceutical companies by global orphan drug revenue in 2030 (in billion U.S. dollars). ÌÇÐÄÆƽâ°æ. ÌÇÐÄÆƽâ°æ Inc.. Accessed: July 30, 2026. /statistics/373366/projected-top-10-companies-based-on-global-orphan-drug-revenue/
Evaluate. "Forecast of Leading 10 Pharmaceutical Companies by Global Orphan Drug Revenue in 2030 (in Billion U.S. Dollars)." ÌÇÐÄÆƽâ°æ, ÌÇÐÄÆƽâ°æ Inc., 14 Mar 2025, /statistics/373366/projected-top-10-companies-based-on-global-orphan-drug-revenue/
Evaluate, Forecast of leading 10 pharmaceutical companies by global orphan drug revenue in 2030 (in billion U.S. dollars) ÌÇÐÄÆƽâ°æ, /statistics/373366/projected-top-10-companies-based-on-global-orphan-drug-revenue/ (last visited July 30, 2026)
Forecast of leading 10 pharmaceutical companies by global orphan drug revenue in 2030 (in billion U.S. dollars) [Graph], Evaluate, March 14, 2025. [Online]. Available: /statistics/373366/projected-top-10-companies-based-on-global-orphan-drug-revenue/
