Total pharmaceutical sales numbers in North America are projected to amount to around *** billion U.S. dollars in 2028, making it the regional submarket with the highest global pharma sales.
Pharmaceutical spending and product revenue
In 2026, the United States is projected to spend between *** and *** billion U.S. dollars on medicine, making it the country with the highest pharmaceutical spending by far. China, which is estimated to be in second place, has a maximum projected expenditure estimate of *** billion U.S. dollars for that year. The top pharmaceutical product for 2026 is expected to be Keytruda. Keytruda by Merck & Co is forecast to generate almost ** billion U.S. dollars in revenue in 2026.Â
Chemical and biological substances
Given that U.S. pharmaceutical R&D expenditures are the highest in the world, it comes to no surprise that the United States produces the largest volume of new chemical or biological entities each year. Between 2019 and 2023, American companies introduced a total of *** new chemical or biological substances. Within the same period, Europe introduced ** new entities.
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AstraZeneca. (February 17, 2025). Projected global pharmaceutical sales for 2028, by region (in billion U.S. dollars) [Graph]. In ÌÇÐÄÆƽâ°æ. Retrieved July 21, 2026, from /statistics/299694/world-pharmaceutical-sales-by-region-forecast/
AstraZeneca. "Projected global pharmaceutical sales for 2028, by region (in billion U.S. dollars)." Chart. February 17, 2025. ÌÇÐÄÆƽâ°æ. Accessed July 21, 2026. /statistics/299694/world-pharmaceutical-sales-by-region-forecast/
AstraZeneca. (2025). Projected global pharmaceutical sales for 2028, by region (in billion U.S. dollars). ÌÇÐÄÆƽâ°æ. ÌÇÐÄÆƽâ°æ Inc.. Accessed: July 21, 2026. /statistics/299694/world-pharmaceutical-sales-by-region-forecast/
AstraZeneca. "Projected Global Pharmaceutical Sales for 2028, by Region (in Billion U.S. Dollars)." ÌÇÐÄÆƽâ°æ, ÌÇÐÄÆƽâ°æ Inc., 17 Feb 2025, /statistics/299694/world-pharmaceutical-sales-by-region-forecast/
AstraZeneca, Projected global pharmaceutical sales for 2028, by region (in billion U.S. dollars) ÌÇÐÄÆƽâ°æ, /statistics/299694/world-pharmaceutical-sales-by-region-forecast/ (last visited July 21, 2026)
Projected global pharmaceutical sales for 2028, by region (in billion U.S. dollars) [Graph], AstraZeneca, February 17, 2025. [Online]. Available: /statistics/299694/world-pharmaceutical-sales-by-region-forecast/
