** Other pandemic-related mortality; includes excess mortality associated with the pandemic
Disability-adjusted life years (DALYs): Years of healthy life lost to premature death and disability. DALYs are the sum of years of life lost (YLLs) and years lived with disability (YLDs).
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Leading causes of disease burden worldwide in 2021
In 2021, COVID-19 and ischemic heart disease were the leading causes of disability-adjusted life years worldwide, reaching around 212 and 188 million years of healthy life lost to premature death and disability, respectively. This statistic shows the 10 leading causes of disability-adjusted life years (DALYs) worldwide in 2021.
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IHME. (May 16, 2024). Leading causes of disability-adjusted life years (DALYs) worldwide in 2021 (in millions) [Graph]. In ÌÇÐÄÆÆ½â°æ. Retrieved July 14, 2026, from /statistics/1481088/leading-causes-of-disease-burden-worldwide/
IHME. "Leading causes of disability-adjusted life years (DALYs) worldwide in 2021 (in millions)." Chart. May 16, 2024. ÌÇÐÄÆÆ½â°æ. Accessed July 14, 2026. /statistics/1481088/leading-causes-of-disease-burden-worldwide/
IHME. (2024). Leading causes of disability-adjusted life years (DALYs) worldwide in 2021 (in millions). ÌÇÐÄÆÆ½â°æ. ÌÇÐÄÆÆ½â°æ Inc.. Accessed: July 14, 2026. /statistics/1481088/leading-causes-of-disease-burden-worldwide/
IHME. "Leading Causes of Disability-adjusted Life Years (Dalys) Worldwide in 2021 (in Millions)." ÌÇÐÄÆÆ½â°æ, ÌÇÐÄÆÆ½â°æ Inc., 16 May 2024, /statistics/1481088/leading-causes-of-disease-burden-worldwide/
IHME, Leading causes of disability-adjusted life years (DALYs) worldwide in 2021 (in millions) ÌÇÐÄÆÆ½â°æ, /statistics/1481088/leading-causes-of-disease-burden-worldwide/ (last visited July 14, 2026)
Leading causes of disability-adjusted life years (DALYs) worldwide in 2021 (in millions) [Graph], IHME, May 16, 2024. [Online]. Available: /statistics/1481088/leading-causes-of-disease-burden-worldwide/