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This report presents key facts and figures on small and mid-sized biotech companies which are the key driver of innovation for the whole biopharma sector. Small and mid-sized enterprises (SMEs) are responsible for most of the new breakthrough therapies and technologies. This report provides a good introduction into the biotech SME landscape, thereby focusing on two SMEs which made it to the big scene due to their COVID-19 vaccines: BioNTech and Moderna.