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This statistic depicts the percentage of select orphan drugs that were utilized in select way in the U.S. between 2012 to 2014, by utilization type. According to the data, 95 percent of Gralise usage was for off-label use. Orphan drugs, once approved, are sometimes expanded to cover several other indications. In fact, many orphan drugs are utilized more often in non-orphan areas than in the original aimed orphan area.