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This statistic presents the number of people who died from an opioid overdose in the United States between 1999 and 2023. The number of fatal overdoses increased every year and multiplied by ten over this period, reaching its peak in 2022 with more than 81,800 deaths due to an opioid overdose.

Among the substances considered by U.S. health authorities are natural opioids such as opium or heroin, methadone, and synthetic opioids. These substances are found both on the black market and in certain medications, such as painkillers. Powerful analgesics are also prescribed, such as fentanyl, which can lead, after medical use, to a true opioid addiction.