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As of 2023, Kaiser Permanente , based in Oakland, California, was the largest health system in the United States when ranked by the number of physicians affiliated with the system. It had nearly 26 thousand physicians affiliated with the organization.

Meanwhile, the Hospital Corporation of America , based in Nashville, Tennessee, was in second place when ranked by the number of physicians, but was the largest health system in the United States when ranked by the number of hospitals. HCA Healthcare is also the largest U.S. health system when ranked by the number of beds and, as expected, by net patient revenue.