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In Los Angeles County, methamphetamine accounted for the highest share of overdose deaths among people experiencing homelessness (PEH) in the 12 months before and after the COVID-19 pandemic onset, contributing to approximately three-quarters of all overdose deaths in both years. Fentanyl ranked as the second leading cause of overdose death in both periods, but showed the largest increase in its contribution over the analyzed timeframe. This statistic depicts the percentage of deaths among people experiencing homelessness by overdose pre- and post-COVID-19 pandemic in Los Angeles County, by drug type.